TCO-PEG4-Acid Chemical Properties

Boiling point:

574.5±50.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

TCO-PEG4-Acid Usage And Synthesis

Description

TCO-PEG4-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. , TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media.

TCO-PEG4-Acid(1802913-21-8)Related Product Information

• TCO-PEG4-NHS Ester
• TCO-PEG12-DBCO
• (4E)-TCO-PEG3-amine
• (2E)-TCO-PNB ester
• TCO-PEG4-NHS ester
• (4E)-TCO-PEG4-DBCO
• (4E)-TCO-amine
• BDP FL-PEG4-(4E)-TCO
• trans-Cyclooctene-maleimide
• (4E)-TCO-PEG4-amine
• TCO-PEG3-Amine
• TCO-carbonate
• TCO/E- active ester (p-NPE) / equatorial
• TCO4-PEG3-NHS
• TCO4-PEG3-Maleimide
• TCO-PEG3-acid
• Sulfo-Cy5-(4E)-TCO
• TCO4-PEG7-Maleimide