Tos-PEG13-Tos CAS#: 1456708-45-4

Tos-PEG13-Tos Basic information

Product Name:

Tos-PEG13-Tos

Synonyms:

Tos-PEG12-Tos
Tos-PEG13-Tos
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol, 1,35-bis(4-methylbenzenesulfonate)
Tos-PEG12-Tos/3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol, 1,35-bis(4-methylbenzenesulfonate)
35-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-yl 4-methylbenzene-1-sulfonate

CAS:

1456708-45-4

MF:

C38H62O17S2

MW:

855.02

Mol File:

1456708-45-4.mol

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Tos-PEG13-Tos Usage And Synthesis

Description

Tos-PEG13-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Tos-PEG13-TosSupplier

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