2-HYDROXY-5-METHYLBENZOPHENONE Chemical Properties

Melting point:

83-85 °C (lit.)

Boiling point:

312.08°C (rough estimate)

Density 

1.1035 (rough estimate)

refractive index 

1.6000 (estimate)

pka

8.24±0.43(Predicted)

form 

powder to crystal

color 

Light orange to Yellow to Green

CAS DataBase Reference

1470-57-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29145000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2-HYDROXY-5-METHYLBENZOPHENONE Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

2-?Hydroxy-?5-?methylbenzophenone is a general reagent used in the synthesis of anti-bacterial and anti-fungal agents.

Preparation

Preparation by condensation of benzotrichloride with p-cresol,
? in the presence of aluminium chloride in carbon disulfide for 2 h (75%). The 6,12-diphenyl-2,8-dimethyl-6,12-epoxy-6H,12H-dibenzo[b,f] dioxocin, an intermediate compound, was also formed under these conditions (29%). This “dioxocin”, by hydrolysis with concentrated sulfuric acid at r.t., gave the expected ketone (91%);
? in the presence of aqueous sodium hydroxide in a water bath for 4 h (33%) or in 32–40% aqueous sodium hydroxide at 70–80° (67%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1924, 1973 DOI: 10.1021/jo00950a030

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