BENFLUOREX HYDROCHLORIDE CAS#: 23642-66-2

BENFLUOREX HYDROCHLORIDE Basic information

Product Name:

BENFLUOREX HYDROCHLORIDE

Synonyms:

2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est
2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est
2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride
mediator
BENFLUOREX HYDROCHLORIDE
2-[[1-METHYL-2-[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE (ESTER) HCL
2-[[1-METHYL-2[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE ESTER HYDROCHLORIDE
2-((1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)AMINO)ETHYL BENZOATE HYDROCHLORIDE

CAS:

23642-66-2

MF:

C19H20F3NO2.ClH

MW:

387.82

EINECS:

245-801-8

Product Categories:

Amines
Aromatics
Intermediates & Fine Chemicals
Pharmaceuticals

Mol File:

23642-66-2.mol

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BENFLUOREX HYDROCHLORIDE Chemical Properties

Melting point:: 158-159?C
storage temp.: Refrigerator
solubility: Chlorform (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White

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Safety Information

Hazard Codes: Xi
WGK Germany: 2
RTECS: KL8275000
Hazard Note: Irritant
HS Code: 2916399090
Toxicity: LD50 intraperitoneal in mouse: 108mg/kg

MSDS

Language:English Provider:SigmaAldrich

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BENFLUOREX HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Solid

Originator

Mediator,Servier,France,1976

Uses

Hypolipedimic;Increase of glucose penetration and use by cells

Uses

BENFLUOREX HYDROCHLORIDE can be used as an antihyperlipoproteinemic therapeutic and increase of glucose penetration and use by cells.

Manufacturing Process

To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β- hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were added successively 15 parts of 4.7N hydrochloric ether and a solution of 14 parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from 230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)- 2-(β-benzoyloxyethyl)amino propane hydrochloride melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts ether are added, then 10 parts of a concentrated solution of ammonium hydroxide. The mixture is stirred a few minutes until the salt is dissolved, then the ethered solution is poured off and dried. After the ether is eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β- benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.

Therapeutic Function

Antihyperlipidemic, Cardiovascular

BENFLUOREX HYDROCHLORIDESupplier

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954

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