BENFLUOREX HYDROCHLORIDE
BENFLUOREX HYDROCHLORIDE Basic information
- Product Name:
- BENFLUOREX HYDROCHLORIDE
- Synonyms:
-
- 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est
- 2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est
- 2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride
- mediator
- BENFLUOREX HYDROCHLORIDE
- 2-[[1-METHYL-2-[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE (ESTER) HCL
- 2-[[1-METHYL-2[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE ESTER HYDROCHLORIDE
- 2-((1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)AMINO)ETHYL BENZOATE HYDROCHLORIDE
- CAS:
- 23642-66-2
- MF:
- C19H21ClF3NO2
- MW:
- 387.82
- EINECS:
- 245-801-8
- Product Categories:
-
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 23642-66-2.mol
BENFLUOREX HYDROCHLORIDE Chemical Properties
- Melting point:
- 158-159?C
- storage temp.
- Refrigerator
- solubility
- Chlorform (Slightly), Methanol (Slightly), Water (Slightly)
- color
- White
Safety Information
- Hazard Codes
- Xi
- WGK Germany
- 2
- RTECS
- KL8275000
- Hazard Note
- Irritant
- HS Code
- 2916399090
- Toxicity
- LD50 intraperitoneal in mouse: 108mg/kg
MSDS
- Language:English Provider:SigmaAldrich
BENFLUOREX HYDROCHLORIDE Usage And Synthesis
Chemical Properties
White Solid
Originator
Mediator,Servier,France,1976
Uses
Hypolipedimic;Increase of glucose penetration and use by cells
Uses
BENFLUOREX HYDROCHLORIDE can be used as an antihyperlipoproteinemic therapeutic and increase of glucose penetration and use by cells.
Manufacturing Process
To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β-
hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were
added successively 15 parts of 4.7N hydrochloric ether and a solution of 14
parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition
required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from
230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)-
2-(β-benzoyloxyethyl)amino propane hydrochloride
melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts
ether are added, then 10 parts of a concentrated solution of ammonium
hydroxide. The mixture is stirred a few minutes until the salt is dissolved,
then the ethered solution is poured off and dried. After the ether is
eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β-
benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.
Therapeutic Function
Antihyperlipidemic, Cardiovascular
BENFLUOREX HYDROCHLORIDESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 0512-62889106
- business@minshengpharm.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
BENFLUOREX HYDROCHLORIDE(23642-66-2)Related Product Information
- 1,3-Difluorobenzene
- 2,6-Difluorobenzonitrile
- MONO CHLORO BENZENE
- Chlorphenamine maleate
- 5,5-Diphenylhydantoin
- Diphenhydramine Hydrochloride
- Benzhexol hydrochloride
- Ethyl benzoate
- BENFLUOREX HYDROCHLORIDE
- BENFLUOREX HYDROCHLORIDE EPY(CRM STANDARD)
- BENFLUOREX HYDROCHLORIDE FOR SYSTEM SUITABILITY
- BENFLUOREX HYDROCHLORIDE FOR SYSTEM SUITABILITY EPY(CRM STANDARD)