AJMALICINE HYDROCHLORIDE
AJMALICINE HYDROCHLORIDE Basic information
- Product Name:
- AJMALICINE HYDROCHLORIDE
- Synonyms:
-
- RAUBASINE HYDROCHLORIDE
- ajmalicine,monohydrochloride
- gamma-yohimbinehydrochloride
- gamma-yohimbinhydrochloride
- oxayohimban-16-carboxylicacid,16,17-didehydro-19-methyl-,methylester,mon
- D-YOHIMBINE
- DELTA-YOHIMBINE HYDROCHLORIDE
- AJMALICINE HCL
- CAS:
- 4373-34-6
- MF:
- C21H25ClN2O3
- MW:
- 388.89
- EINECS:
- 224-471-9
- Mol File:
- 4373-34-6.mol
AJMALICINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 275-300 °C
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- AX7890000
- F
- 10-23
MSDS
- Language:English Provider:SigmaAldrich
AJMALICINE HYDROCHLORIDE Usage And Synthesis
Uses
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2].
in vivo
Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation[1].
Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
| Animal Model: | Male Wistar rats (300-350 g)[1] |
| Dosage: | 0.5, 1, 2, and 4 mg/kg |
| Administration: | IV, once |
| Result: | Induced a marked dose-dependent inhibition against the pressor response to noradrenaline. |
IC 50
α1-adrenergic receptor; α2-adrenergic receptor
Purification Methods
This hydrochloride crystallises from MeOH or EtOH. Its solubility is 0.315g/100g of H2O at 100o. [Beilstein 27 III/IV 7928.]
References
[1] Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5. DOI:10.1016/0014-2999(84)90698-8
[2] Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52. DOI:10.1016/j.phymed.2009.10.008
[3] Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10 DOI:10.1111/j.1476-5381.1984.tb16514.x
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