Methacetin Chemical Properties

Melting point:

128-130 °C(lit.)

Boiling point:

293.03°C (rough estimate)

Density 

1.1603 (rough estimate)

refractive index 

1.5839 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Crystalline

pka

14.53±0.70(Predicted)

color 

White

Water Solubility 

0.42 g/100 mL (20 ºC)

Merck 

14,51

BRN 

387887

Stability:

Hygroscopic

CAS DataBase Reference

51-66-1(CAS DataBase Reference)

NIST Chemistry Reference

N-(4-Methoxyphenyl)acetic acid amide(51-66-1)

EPA Substance Registry System

Acetamide, N-(4-methoxyphenyl)- (51-66-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/38

Safety Statements 

36-37/39-26

WGK Germany 

1

RTECS 

AE8290000

TSCA 

Yes

HS Code 

29242990

Toxicity

LD50 orl-mus: 1190 mg/kg TXAPA9 19,20,71

MSDS

• Language:English Provider:N-(4-Methoxyphenyl)acetamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Methacetin Usage And Synthesis

Chemical Properties

LIGHT BEIGE CRYSTALLINE POWDER

Uses

Methacetin is evaluated in a breath test to predict early liver disfunction due to valproic acid and other cause. Methacetin breath test (MBT) is a rapid, non-invasive assessment of liver function in acute severe liver disease and a potential key tool in future dignosis.

Definition

ChEBI: Methacetin is a member of the class of acetamides that is paracetamol in which the hydrogen of phenolic hydroxy group has been replaced by a methyl group. It is a member of acetamides and an aromatic ether. It is functionally related to a p-anisidine and a paracetamol.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
The Journal of Organic Chemistry, 42, p. 3755, 1977
Organic Syntheses, Coll. Vol. 3, p. 661, 1955

Safety Profile

Moderately toxic by ingestion andother unspecified routes. When heated to decomposition itemits toxic fumes of NOx.

Methacetin(51-66-1)Related Product Information

• 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER
• N-(4-METHOXYPHENYL)MALEAMIC ACID
• 3-HYDROXY-P-BUTYROPHENETIDINE
• BRUCINE SULFATE
• Phenacetin
• 3-Hydroxy-4'-methoxy-2-naphthanilide
• N-(4-ETHOXYPHENYL)MALEAMIC ACID
• 3'-Amino-4'-methoxyacetanilide
• 10,11-Dimethoxystrychnine
• 4'-Methoxyacetoacetanilide
• N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide
• Methacetin
• n-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diethylamino)-4-methoxyphenyl]-acetamide
• 2-CHLORO-N-(2-METHOXYPHENYL)ACETAMIDE
• p-Toluidine
• Anisole
• 4-METHOXYPHENYLACETAMIDE
• p-Anisidine