CL 218872 Chemical Properties

Melting point:

193-194 °C(Solv: methanol (67-56-1))

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml

form 

A solid

pka

0.48±0.30(Predicted)

color 

Light yellow to brown

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CL 218872 Usage And Synthesis

Uses

CL 218872 is a useful research chemical.CL 218872 is a putative anxiolytic.

Uses

CL 218872 is a benzodiazepine receptor (BZR) partial agonist and a putative anxiolytic.

Definition

ChEBI: 3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine is a member of pyridazines and a ring assembly.

Biological Activity

Benzodiazepine agonist displaying selectivity for α 1 subunit-containing GABA A receptors (K i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α 1, α 2, α 3, α 4, α 5 and α 6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo .

storage

Store at RT

CL 218872(66548-69-4)Related Product Information

• 4-AMINO-3,5-DIMETHYL-1,2,4-TRIAZOLE
• CL 218872