Basic information Safety Supplier Related

GSK583

Basic information Safety Supplier Related

GSK583 Basic information

Product Name:
GSK583
Synonyms:
  • GSK583
  • SK583
  • 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
  • RIP2 kinase inhibitor 583
  • CS-2216
  • GSK583, >98%
  • GSK-583;GSK 583
  • 4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
CAS:
1346547-00-9
MF:
C20H19FN4O2S
MW:
398.45
Mol File:
1346547-00-9.mol
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GSK583 Chemical Properties

Boiling point:
652.9±55.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO (up to at least 25 mg/ml).
pka
12.59±0.40(Predicted)
form 
solid
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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GSK583 Usage And Synthesis

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

Uses

GSK 583, is a selective inhibitor of RIP-like interacting CLARP kinase RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

storage

Store at +4°C

References

1) Haile?et al.?(2016),?The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem.,?59?4867 2) Goncharov?et al.?(2018),?Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell,?69?551

GSK583Supplier

Shanghai JiYi Biotechnology Co. Ltd. Gold
Tel
13621943973
Email
sales@shjiyipharmatech.com
Suzhou Ran enzyme Biotechnology Co., Ltd. Gold
Tel
0512-0512-62793604 18015430729
Email
116667374@qq.com
Jingmo (Xiamen) Biotechnology Co., Ltd Gold
Tel
13621943973
Email
sales@jamxmpharmatech.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com