5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to light brown Solid

Safety Information

HS Code 

2933998090

5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Usage And Synthesis

Uses

5-fluoro-1H-indazole-3-carbaldehyde is used as a key intermediate in the synthesis of a variety of polyfunctionalized 3-substituted indazoles.

Synthesis

Step 3: Manganese dioxide (1.12 g, 12.9 mmol) was added to a solution of (5-fluoro-1H-indazol-3-yl)methanol (0.215 g, 1.29 mmol) in ethyl acetate (10 mL) at room temperature. The reaction mixture was stirred overnight and filtered through diatomaceous earth. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: chloroform/methanol) to afford 5-fluoro-1H-indazole-3-carbaldehyde (0.150 g, 70% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.41 (ddd, J = 2.2,8.8,9.5 Hz, 1H), 7.75-7.81 (m, 2H), 10.18 (s, 1H), 14.32 (br s, 1H).

References

[1] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0352

5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE(485841-48-3)Related Product Information

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