4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide Chemical Properties

Density 

1.46±0.1 g/cm3(Predicted)

solubility 

Acetone (Slightly), Chloroform (Slightly)

pka

14.46±0.46(Predicted)

form 

Solid

color 

Pale Yellow to Light Yellow

4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide Usage And Synthesis

Uses

Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.

4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide(915087-16-0)Related Product Information

• Enzalutamide Impurity 20
• 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester
• Enzalutamide
• EnzalutaMide IMpurity
• methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate
• 4-Bromo-2-fluorobenzoic acid
• 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide
• Enzalutamide
• Methyl 4-bromo-2-fluorobenzoate
• 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE
• Enzalutamide carboxylic acid
• N-desMethyl EnzalutaMide
• [2H6]-Enzalutamide
• Enzalutamide Impurity 7
• 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
• Enzalutamide Impurity 7
• 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-
• 4-amino-2-fluoro-N-methylbenzamide