Acid-PEG4-t-butyl ester Chemical Properties

Boiling point:

460.1±40.0 °C(Predicted)

Density 

1.107±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C16H30O8/c1-16(2,3)24-15(19)5-7-21-9-11-23-13-12-22-10-8-20-6-4-14(17)18/h4-13H2,1-3H3,(H,17,18)

InChIKey

LXMHKDZTUDTSCT-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCC(O)=O

Acid-PEG4-t-butyl ester Usage And Synthesis

Description

Acid-PEG4-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR[1].

IC 50

PEGs; Alkyl/ether

References

[1] Jennifer PITZEN , et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.

Acid-PEG4-t-butyl ester(1835759-85-7)Related Product Information

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