Aminooxy-PEG2-alcohol Chemical Properties

Boiling point:

265.9±20.0 °C(Predicted)

Density 

1.116±0.06 g/cm3(Predicted)

pka

14.39±0.10(Predicted)

Aminooxy-PEG2-alcohol Usage And Synthesis

Description

Aminooxy-PEG2-alcohol is a short PEG linker containing an aminooxy group and a a hydroxyl group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c

Aminooxy-PEG2-alcohol(185022-12-2)Related Product Information

• Aminooxy-PEG3-NH-Boc
• Boc-Aminooxy-PEG3-acid
• Aminooxy-PEG7-methane
• Aminooxy-PEG3-methane
• Boc-Aminooxy-PEG2-amine
• Aminooxy-PEG4-t-butyl ester
• Aminooxy-PEG4-alcohol
• Aminoxy-PEG4-acid
• Aminooxy-PEG8-methane
• Aminooxy-PEG3-thiol
• Aminooxy-PEG2-methane
• Boc-Aminooxy-PEG3-amine
• Aminooxy-PEG3-t-butyl ester
• Aminoxy-PEG3-acid