Basic information Safety Supplier Related

Edoxaban-d6

Basic information Safety Supplier Related

Edoxaban-d6 Basic information

Product Name:
Edoxaban-d6
Synonyms:
  • Edoxaban-d6
  • N-[(1S,2R,4S)-4-[bis(trideuteriomethyl)carbamoyl]-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]-N'-(5-chloropyridin-2-yl)oxamide
  • [2H6]-Edoxaban
  • Edoxaban hydrochloride salt
CAS:
1304701-57-2
MF:
C24H30ClN7O4S
MW:
548.06
Mol File:
1304701-57-2.mol
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Edoxaban-d6 Chemical Properties

Melting point:
>205°C (dec.)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), Dichloromethane (Slightly)
form 
Solid
color 
Pale Orange to Pale Red
Stability:
Hygroscopic
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Edoxaban-d6 Usage And Synthesis

Description

Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively). It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.

Uses

Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.

Edoxaban-d6Supplier

Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Email
han_yajun@dctc.daicel.com
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Email
sales@artisbio.com
Clearsynth Canada Inc.
Tel
+1.415.685.4395
Email
enquiry@clearsynth.com
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Email
amber@biochempartner.com
Shenzhen Popeye Biotechnology Co. Ltd.
Tel
0755-86320212
Email
popeye02@qq.com
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