N-ME-AIB-OH HCL Chemical Properties

Melting point:

300 °C

Boiling point:

192.5±23.0 °C(Predicted)

Density 

1.2000 (estimate)

refractive index 

1.4650 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Water Solubility 

almost transparency in Water

form 

powder to crystal

pka

2.17±0.10(Predicted)

color 

White to Almost white

BRN 

1746984

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

2922.49.8000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

N-ME-AIB-OH HCL Usage And Synthesis

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

α-(Methylamino)isobutyric acid (MeAIB) has been used:

• as a system A transport system inhibitor to perform inhibition experiments
• as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
• as an N-acetyltransferase (SNAT) inhibitor in Hankμs balanced salt solution (HBSS) to study its influence on the uptake of 14C-cysteine/ radioactive-labeled cysteine

Definition

ChEBI: Alpha-(methylamino)isobutyric acid is a non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group. It has a role as a human urinary metabolite. It is an alanine derivative, a non-proteinogenic alpha-amino acid and a secondary amino compound. It is functionally related to an isobutyric acid. It is a conjugate acid of a N-methyl-aminoisobutyrate zwitterion.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 8120, 1995 DOI: 10.1021/jo00130a002

Biological Activity

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

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