4-Bromomethylbenzoic acid Chemical Properties

Melting point:

224-229 °C(lit.)

Boiling point:

252.95°C (rough estimate)

Density 

1.5313 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Store below +30°C.

form 

Crystalline Powder

pka

4.10±0.10(Predicted)

color 

White to beige

Water Solubility 

Soluble in water.

BRN 

1862870

InChIKey

CQQSQBRPAJSTFB-UHFFFAOYSA-N

CAS DataBase Reference

6232-88-8(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 4-(bromomethyl)- (6232-88-8)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3261

WGK Germany 

3

F 

19-21

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29163900

MSDS

• Language:English Provider:4-Bromomethylbenzoic acid
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4-Bromomethylbenzoic acid Usage And Synthesis

Chemical Properties

white to beige crystalline powder

Uses

4-(Bromomethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.

Uses

4-(Bromomethyl)benzoic acid acts as an intermediate in the synthesis of eprosartan, which is used as an antihypertensive agent. Further, it is used in the preparation of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), which is a second generation photosensitizer. In addition to this, it is used in the preparation of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.

Uses

4-(Bromomethyl)benzoic acid was used in the chemical modification of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), second generation photosensitizer. It was also used in the synthesis of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.

Purification Methods

Crystallise the acid from pKEst Me2CO. [Beilstein 9 IV 1745.]

4-Bromomethylbenzoic acid(6232-88-8)Related Product Information

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