Basic information Safety Supplier Related

AZD2098

Basic information Safety Supplier Related

AZD2098 Basic information

Product Name:
AZD2098
Synonyms:
  • AZD2098
  • AZD 2098 NEW
  • AZD 2098;AZD-2098;AZD2098
  • 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
  • Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-
  • AZD-2098 >=98% (HPLC)
  • AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098
  • AZD 2098 - Bio-X
CAS:
566203-88-1
MF:
C11H9Cl2N3O3S
MW:
334.18
EINECS:
604-604-1
Mol File:
566203-88-1.mol
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AZD2098 Chemical Properties

Melting point:
185-186°C
Boiling point:
489.3±55.0 °C(Predicted)
Density 
1.569±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
powder
pka
5.56±0.40(Predicted)
color 
white to beige
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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AZD2098 Usage And Synthesis

Description

AZD-2098 (566203-88-1) is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CCR2b, CCR5, CCR7, and CCR8 @ 10 μM.

Uses

AZD-2098 is a potent and selective agonist of CCR4 chemokine receptor with IC50 values ranging from 10 to 25 nM across different species. CCR4 is involved in activation and migration of Th2 lymphocytes to the lungs in response to allergens. Treating sensitised rats results in reduced inflammation of lung tissue.

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ~120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

storage

Store at +4°C

References

Kindon et al. (2017), Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists; ACS Med. Chem. Lett. 8 981

AZD2098Supplier

Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com