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N-Carbobenzyloxy-L-valine

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N-Carbobenzyloxy-L-valine Basic information

Product Name:
N-Carbobenzyloxy-L-valine
Synonyms:
  • Z-VAL
  • Z-VALINE
  • Z-VAL-OH
  • N-Carbobenzyloxy-L-valine Cbz-L-Valine
  • CBZ-L-Valine (Z-Val-OH)
  • Z-L-VALINE
  • Z-L-VAL-OH
  • N-Cbz-L-valine Z-Val-OH
CAS:
1149-26-4
MF:
C13H17NO4
MW:
251.28
EINECS:
214-562-1
Product Categories:
  • Valine [Val, V]
  • Z-Amino Acids and Derivatives
  • Amino Acids
  • Amino Acids (N-Protected)
  • Biochemistry
  • Cbz-Amino Acids
  • Miscellaneous Biochemicals
  • chiral
  • PROTECTED AMINO ACID & PEPTIDES
  • Chiral Compounds
  • Cbz-Amino acid series
Mol File:
1149-26-4.mol
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N-Carbobenzyloxy-L-valine Chemical Properties

Melting point:
62-64 °C(lit.)
alpha 
-4 º (c=2,acetic acid)
Boiling point:
394.43°C (rough estimate)
Density 
0,926g/cm
refractive index 
-4.3 ° (C=2, AcOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Acetic Acid, DMSO (Slightly), Ethanol (Slightly)
pka
4.00±0.10(Predicted)
form 
Crystalline Powder
color 
White to off-white
optical activity
[α]20/D 4.2±0.5°, c = 2 in chloroform
BRN 
2056617
InChI
InChI=1S/C13H17NO4/c1-9(2)11(12(15)16)14-13(17)18-8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3,(H,14,17)(H,15,16)/t11-/m0/s1
InChIKey
CANZBRDGRHNSGZ-NSHDSACASA-N
SMILES
C(O)(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O
CAS DataBase Reference
1149-26-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
38-43-36/37/38-20/21/22
Safety Statements 
36/37-36-26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29242990

MSDS

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N-Carbobenzyloxy-L-valine Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

Imatinib intermediate

Uses

Valaciclovir intermediate

Uses

N-Cbz-L-valine is an N-Cbz-protected form of L-Valine (V094205). L-Valine is an essential amino acid that is used as an ingredient in cosmetic formulations, pharmaceuticals, and animal feed products. L-valine is also important for growth and ammonia detoxification in humans.

Synthesis Reference(s)

Synthesis, p. 738, 1985 DOI: 10.1055/s-1985-31329

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