[D-PRO2, D-TRP7,9]-SUBSTANCE P
[D-PRO2, D-TRP7,9]-SUBSTANCE P Basic information
- Product Name:
- [D-PRO2, D-TRP7,9]-SUBSTANCE P
- Synonyms:
-
- dt79
- ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 3HCL 6H2O
- ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 HYDROCHLORIDE
- [D-PRO2, D-TRP7,9]-SUBSTANCE P
- [D-PRO2,D-TRP7,9]-SUBSTANCE P 3HCL 6H2O
- [D-PRO2,D-TRP7,9]-SUBSTANCE P HYDROCHLORIDE
- (D-pro2
- CAS:
- 80434-86-2
- MF:
- C74H106N20O13S
- MW:
- 1515.82
- Mol File:
- 80434-86-2.mol
[D-PRO2, D-TRP7,9]-SUBSTANCE P Chemical Properties
- storage temp.
- −20°C
MSDS
- Language:English Provider:SigmaAldrich
[D-PRO2, D-TRP7,9]-SUBSTANCE P Usage And Synthesis
Uses
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].
in vivo
[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].
| Animal Model: | Adult pigmented rabbits (1.5-3 kg)[1] |
| Dosage: | 0.03, 0.3, 3, and 30 nmol |
| Administration: | Intravitreal injection or topical application onto the eye, 60 μL |
| Result: | Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye. |
References
[1] Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. DOI:10.1126/science.6171036
[2] H?kanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. DOI:10.1111/j.1476-5381.1982.tb09348.x
[3] Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. DOI:10.5114/fn.2020.100066
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