2-METHOXY-3,5-DIBROMO-PYRIDINE Chemical Properties

Melting point:

46-51℃

Boiling point:

235.7±35.0 °C(Predicted)

Density 

1.919±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

-1.31±0.20(Predicted)

color 

White to Orange to Green

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-22

Safety Statements 

26-36-45

RIDADR 

UN 2811

WGK Germany 

1

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2933399990

2-METHOXY-3,5-DIBROMO-PYRIDINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2-methoxy-3,5-dibromopyridine from 5-bromo-2-methoxypyridine was as follows: bromine (17.8 g, 111 mmol) was slowly added to a mixed solution containing 5-bromo-2-methoxypyridine (12.0 g, 63.8 mmol), sodium acetate (5.23 g, 63.8 mmol) and acetic acid (65 mL). The reaction mixture was stirred at 80 °C for 4 hours, followed by continued stirring at room temperature for 12 hours. After completion of the reaction, the mixture was diluted with ether and washed sequentially with water, saturated sodium bicarbonate solution and brine. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography with the eluent being a petroleum ether solution of 1-5% ethyl acetate to give 10.6 g of the target product 2-methoxy-3,5-dibromopyridine. The product was characterized by 1H NMR (300 MHz, DMSO-d6) with chemical shifts of 8.20-8.40 (m, 2H) and 3.92 (s, 3H).

References

[1] Patent: US2010/81673, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2015/210671, 2015, A1. Location in patent: Paragraph 0173; 0181; 0182
[3] Patent: US9145393, 2015, B2. Location in patent: Page/Page column 37; 38

2-METHOXY-3,5-DIBROMO-PYRIDINE(13472-60-1)Related Product Information

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