RIBOFLAVINE TETRABUTYRATE
RIBOFLAVINE TETRABUTYRATE Basic information
- Product Name:
- RIBOFLAVINE TETRABUTYRATE
- Synonyms:
-
- RIBOFLAVINE TETRABUTYRATE
- RIBOFLAVIN TETRABUTYRATE
- VITAMIN B2 TETRABUTYRATE
- hibon
- riboflavin,2’,3’,4’,5’-tetrabutanoate
- riboflavin,2’,3’,4’,5’-tetrabutyrate
- Riboflavinebutyrate
- [(2S,3S,4R)-3,4,5-tri(butanoyloxy)-1-(7,8-dimethyl-2,4-dioxo-benzo[g]pteridin-10-yl)pentan-2-yl] butanoate
- CAS:
- 752-56-7
- MF:
- C33H44N4O10
- MW:
- 656.72
- EINECS:
- 212-034-5
- Product Categories:
-
- Biochemistry
- Vitamins
- Vitamins and derivatives
- Mol File:
- 752-56-7.mol
RIBOFLAVINE TETRABUTYRATE Chemical Properties
- Melting point:
- 149 °C
- Density
- 1.250 g/cm3
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 9.83±0.70(Predicted)
- color
- Yellow
- Merck
- 14,8200
- InChIKey
- MJNIWUJSIGSWKK-FSGGQHMVSA-N
- SMILES
- CC1C(C)=CC2N=C3C(=NC(=O)NC3=O)N(C[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)COC(=O)CCC)C=2C=1
RIBOFLAVINE TETRABUTYRATE Usage And Synthesis
Uses
Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.
Definition
ChEBI: Riboflavin butyrate is a flavin.
in vivo
Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid[1]. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver [2].
References
[1] Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8. DOI:10.3177/jnsv.20.81
[2] Okuno E, et al. Effect of chronic administration of riboflavin 2',3',4',5'-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42. DOI:10.3177/jnsv.29.637
[3] Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavin nucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9. PMID:5347449
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