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Triethylene glycol dimethyl ether

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Triethylene glycol dimethyl ether Basic information

Product Name:
Triethylene glycol dimethyl ether
Synonyms:
  • (CH3O(CH2)2OCH2)2
  • Ansul Ether 161
  • Triethylene Glycol DiMethyl Ether (stabilized with BHT)
  • 1,2-Bis(2-methoxyethoxy)ethane 2,5,8,11-Tetraoxadodecane Triglyme
  • TRIETHYLENE GLYCOL DIMETHYL ETHER FOR SY
  • 1,2-Bis(2-Methoxyethoxy) Ethane, Reagent
  • Triethylene glycol diMethyl et
  • Triethylene glycol dimethyl ether ReagentPlus(R), 99%
CAS:
112-49-2
MF:
C8H18O4
MW:
178.23
EINECS:
203-977-3
Product Categories:
  • Building Blocks
  • C2 to C8
  • Chemical Synthesis
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
  • Functional Materials
  • Plasticizer
  • Polyalcohol Ethers, Esters (Plasticizer)
  • Aliphatics
  • Isotope Labelled Compounds
Mol File:
112-49-2.mol
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Triethylene glycol dimethyl ether Chemical Properties

Melting point:
−45 °C(lit.)
Boiling point:
216 °C(lit.)
Density 
0.986 g/mL at 25 °C(lit.)
vapor density 
>4.7 (vs air)
vapor pressure 
1.2 hPa (20 °C)
refractive index 
n20/D 1.423(lit.)
Flash point:
231 °F
storage temp. 
Store below +30°C.
solubility 
>1000g/l soluble
form 
Liquid
color 
APHA: ≤20
explosive limit
0.7%(V)
Water Solubility 
Soluble
Sensitive 
Hygroscopic
Merck 
14,9692
BRN 
1700630
Dielectric constant
7.5
InChIKey
YFNKIDBQEZZDLK-UHFFFAOYSA-N
LogP
-0.52 at 20℃
CAS DataBase Reference
112-49-2(CAS DataBase Reference)
NIST Chemistry Reference
2,5,8,11-Tetraoxadodecane(112-49-2)
EPA Substance Registry System
Triethylene glycol dimethyl ether (112-49-2)
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Safety Information

Hazard Codes 
T
Risk Statements 
61-19-62
Safety Statements 
53-45
WGK Germany 
1
RTECS 
XF0665000
3
Autoignition Temperature
375 °F
TSCA 
Yes
HS Code 
29094990
Toxicity
LD50 orally in Rabbit: 5390 mg/kg

MSDS

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Triethylene glycol dimethyl ether Usage And Synthesis

Chemical Properties

Water-white liquid; mild ether odor. D 0.9862 (20/20C), refr index 1.4233 (20C), flash p 232F (111C), bp 216.0C (760mmHg), 153.6C (100 mm Hg), fp ?46C. Completely soluble in water and hydrocarbons at 20C. May contain peroxides. Combustible.

Uses

Triethylene glycol dimethyl ether is used as a solvent for gases and coupling immiscible liquid. It is also used to prepare perfluoro-triethyleneglycoldimethylether.

Uses

Triethylene glycol dimethyl ether may be used as an analytical standard for the quantification of the analyte in water samples using in vitro bioassays and chemical screening technique.

Uses

Labelled Triglyme. It is used as a solvent.

Definition

ChEBI: A polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms.

Application

Triethylene glycol dimethyl ether is a member of the glycol ether class of industrial solvents. These solvents are widely used to manufacture protective coatings such as lacquers, metal coatings, baking enamels, phenolic varnishes, epoxy resin coatings, and alkyl resins[1].

Reactivity Profile

TRIETHYLENE GLYCOL DIMETHYL ETHER forms explosive peroxides on prolonged exposure to air. Its decomposition products may be sensitive to shock. The bulk chemical is stable for 2 weeks at temperatures up to 140° F when protected from light. TRIETHYLENE GLYCOL DIMETHYL ETHER is incompatible with strong oxidizers. TRIETHYLENE GLYCOL DIMETHYL ETHER is also incompatible with strong acids. TRIETHYLENE GLYCOL DIMETHYL ETHER may react with peroxides, oxygen, nitric acid and sulfuric acid. .

Flammability and Explosibility

Non flammable

Toxicology

Triethylene glycol dimethyl ether (triEGdiME) is a widely used organic solvent. It is structurally related to several compounds that produce reproductive and developmental toxicity, including teratogenicity in laboratory animals. In the present studies, triEGdiME (0, 75, 125, 175, or 250 mg/kg/day) is administered by gavage in distilled water to timed-pregnant New Zealand white rabbits (15-25 dams/group) during major organogenesis [Gestational Days (gd) 6-19]. In the triEGdiME study, clinical signs of toxicity were minimal, and there was no increased maternal mortality. Maternal body weight and gravid uterine weight were significantly reduced at 250 mg/kg/day, whereas maternal weight gain during treatment was significant. They were depressed at doses of 175 mg/kg/day and above. Prenatal mortality was significantly increased at 250 mg triEGdiME/kg/day. TriEGdiME at doses of 175 and 250 mg/kg/day caused a significant increase in the incidence of malformed fetuses per litter. Malformations noted most frequently in fetuses of normal size included anonychia (missing toenails with no digital abnormalities), abnormally small spleen, and hydronephrosis[1].

Purification Methods

Reflux it with, and distil it from sodium hydride or LiAlH4. [Beilstein 1 IV 2401.]

Triethylene glycol dimethyl ether Supplier

Anhui Lixing Chemical Co., Ltd. Gold
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