Bisindolylmaleimide V
Bisindolylmaleimide V Basic information
- Product Name:
- Bisindolylmaleimide V
- Synonyms:
-
- 1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045
- 1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
- 1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione
- 1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
- 3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
- 3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione
- Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
- BISINDOLYLMALEIMIDE V
- CAS:
- 113963-68-1
- MF:
- C21H15N3O2
- MW:
- 341.36
- EINECS:
- 604-604-1
- Mol File:
- 113963-68-1.mol
Bisindolylmaleimide V Chemical Properties
- Melting point:
- >260 °C
- Boiling point:
- 655.7±55.0 °C(Predicted)
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 15.89±0.30(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 113963-68-1(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
Bisindolylmaleimide V Usage And Synthesis
Description
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.
Definition
ChEBI: Ro 31-6045 is a member of indoles.
References
1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177
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