Bisindolylmaleimide V Chemical Properties

Melting point:

>260 °C

Boiling point:

655.7±55.0 °C(Predicted)

Density 

1.450±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO: soluble

form 

solid

pka

15.89±0.30(Predicted)

color 

Orange

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

CAS DataBase Reference

113963-68-1(CAS DataBase Reference)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Bisindolylmaleimide V Usage And Synthesis

Description

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

Definition

ChEBI: Ro 31-6045 is a member of indoles.

References

1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177

Bisindolylmaleimide V(113963-68-1)Related Product Information

• Succinimide
• 2-Methylindole
• Thiophanate-methyl
• Kresoxim-methyl
• N-Ethylmaleimide
• N-Phenylmaleimide
• N-Benzylmaleimide
• Pyrrole
• Methyl salicylate
• Methyl acetate
• Maleimide
• Tribenuron methyl
• METSULFURON METHYL
• Bismaleimide
• O-Phthalimide
• Methyl
• Polyamideimide
• DIALIFOS