3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Chemical Properties

Density 

1.90±0.1 g/cm3(Predicted)

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

12.69±0.20(Predicted)

form 

Solid

color 

Off-White to Light Grey

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Usage And Synthesis

Uses

3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one is an intermediate in the synthesis of Sitagliptin Triazecine Analog (S491015). Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one(877402-45-4)Related Product Information

• Sitagliptin Impurity 77
• Sitagliptin impurity 5
• Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
• ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
• 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
• Sitagliptin Impurity 34
• 2,4,5-TRIFLUOROBENZYL CHLORIDE
• (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
• Sitagliptin
• Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
• Sitagliptin Impurity 14
• Sitagliptin Defuoro IMpurity 5
• Sitagliptin DeaMino IMpurity 1
• (S)-Sitagliptin Phosphate
• 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
• Sitagliptin Impurity 28
• (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione