MRT-92 HCl salt
MRT-92 HCl salt Basic information
- Product Name:
- MRT-92 HCl salt
- Synonyms:
-
- MRT-92 HCl salt
- CAS:
- 1428307-52-1
- MF:
- C33H35ClN4O5
- MW:
- 603.12
- Mol File:
- 1428307-52-1.mol
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MRT-92 HCl salt Usage And Synthesis
Description
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain.