2-Methoxyethoxymethyl chloride
2-Methoxyethoxymethyl chloride Basic information
- Product Name:
- 2-Methoxyethoxymethyl chloride
- Synonyms:
-
- ALKOXYETHOXYMETHYLCHLORIDE
- BETA-METHOXYETHOXYMETHYL CHLORIDE
- ETHYLENE GLYCOL CHLOROMETHYL METHYL ETHER
- MEM CHLORIDE
- 1-CHLOROMETHOXY-2-METHOXYETHANE
- 1-(Chloromethoxy)-2-methoxyethane~MEM chloride
- Alcoxyethoxymethylchloride
- Methoxxxy ethoxy Chloromethane
- CAS:
- 3970-21-6
- MF:
- C4H9ClO2
- MW:
- 124.57
- EINECS:
- 223-589-8
- Product Categories:
-
- Protection & Derivatization Reagents (for Synthesis)
- Synthetic Organic Chemistry
- Mol File:
- 3970-21-6.mol
2-Methoxyethoxymethyl chloride Chemical Properties
- Melting point:
- 200-202 °C
- Boiling point:
- 50-52 °C/13 mmHg (lit.)
- Density
- 1.091 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.427(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- form
- Liquid
- Specific Gravity
- 1.091
- color
- Clear colorless to yellow
- Water Solubility
- It hydrolyzes with water.
- Sensitive
- Moisture Sensitive
- BRN
- 1900576
- Exposure limits
- ACGIH: TWA 0.001 ppm
- InChIKey
- BIAAQBNMRITRDV-UHFFFAOYSA-N
- CAS DataBase Reference
- 3970-21-6(CAS DataBase Reference)
- NIST Chemistry Reference
- «BETA»-methoxyethoxymethyl chloride(3970-21-6)
- EPA Substance Registry System
- Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 45-10-36/37/38-20/21/22-46-40-23/24/25-20/22
- Safety Statements
- 53-26-36/37/39-45-16-23
- RIDADR
- UN 2810 6.1/PG 2
- WGK Germany
- 3
- F
- 10-21
- Hazard Note
- Toxic
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29091990
MSDS
- Language:English Provider:beta-Methoxyethoxymethyl chloride
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2-Methoxyethoxymethyl chloride Usage And Synthesis
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.
Uses
OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.
Uses
2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.
Purification Methods
Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.
2-Methoxyethoxymethyl chloride Preparation Products And Raw materials
Preparation Products
2-Methoxyethoxymethyl chlorideSupplier
- Tel
- 24-24524889 18640309171
- 236415745@qq.com
- Tel
- 0573-85285100 18627885956
- isenchem@163.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-61259108 18621169109
- market03@meryer.com
- Tel
- 010-88425576
- sales@dhltchem.com
2-Methoxyethoxymethyl chloride(3970-21-6)Related Product Information
- Mepiquat chloride
- 4-Methoxybenzylchloride
- Sodium chloride
- tert-Butyldimethylsilyl chloride
- Polyvinyl chloride
- Choline chloride
- Ammonium chloride
- Calcium chloride
- Benzyl chloride
- Ethoxymethylenemalononitrile
- DIMETHYLTHEXYLSILYL CHLORIDE
- 4-(Chloromethyl)benzoic acid
- Methylene Chloride
- 2-Ethoxyethyl chloroformate
- 1-Chloro-3,5-di-O-toluoyl-2-deoxy-D-ribofuranose
- TRIETHYLENE GLYCOL BIS(CHLOROFORMATE)
- 2-METHOXYETHYL CHLOROFORMATE
- Oxydiethylene bis(chloroformate)