Tetrazine-Acid Chemical Properties

Boiling point:

477.1±47.0 °C(Predicted)

Density 

1.394±0.06 g/cm3(Predicted)

solubility 

DMSO : 50 mg/mL (231.27 mM; Need ultrasonic)

pka

3.66±0.10(Predicted)

Tetrazine-Acid Usage And Synthesis

Description

Tetrazine-Acid was found the fastest kinetics for bioorthogonal reaction with trans-cyclooctene (TCO) as the dienophile. The chemical stability of tetrazines is lower compared to methyltetrazines, but it is in acceptable range and thus can be applied for many applications.

Uses

Tetrazine-acid demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M^-1 s^-1). These have been the fastest kinetics reported for a bio orthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.