3',5'-Dibromo-2'-hydroxyacetophenone Chemical Properties

Melting point:

108-111 °C(lit.)

Boiling point:

307.5±42.0 °C(Predicted)

Density 

1.936±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

8.07±0.23(Predicted)

color 

White to Yellow to Orange

CAS DataBase Reference

22362-66-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2914390090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3',5'-Dibromo-2'-hydroxyacetophenone Usage And Synthesis

Description

3‘,5’-Dibromo-2'-hydroxyacetophenone is a halogenated hydroxyacetophenone derivative which can have good reactivity and is widely used in organic synthesis. Its derivative 5′-bromo-2′-hydroxyacetophenone can be used as a raw material to synthesise a variety of 2-(2-hydroxyphenyl)-1H-indoles by palladium-catalysed reaction with aniline^[1].

Uses

3'',5''-Dibromo-2''-hydroxyacetophenone is a useful reagent in organic synthesis.

Preparation

Preparation by Fries rearrangement of 2,4-dibromophenyl acetate with aluminium chloride without solvent between 150° and 165°.

References

[1] MILAN SUBEDI . Facile Synthesis of 2-(4-Hydroxybiphenyl-3-yl)-1H-indoles from Anilines and 5′-Bromo-2′-hydroxyacetophenone[J]. Synthetic Communications, 2015, 45 14: Pages 1704-1709. DOI:10.1080/00397911.2015.1043390.

3',5'-Dibromo-2'-hydroxyacetophenone(22362-66-9)Related Product Information

• 2-Bromoacetophenone
• 2',6'-Dihydroxyacetophenone
• 2',5'-Dihydroxyacetophenone
• 3,5-Dihydroxyacetophenone
• 3-Nitroacetophenone
• 3'-Hydroxyacetophenone
• 2-HYDROXYACETOPHENONE
• Chalcone
• 4'-Hydroxyacetophenone
• 2',4',6'-Trihydroxyacetophenone monohydrate
• 2'-Hydroxyacetophenone
• Acetophenone
• 4-Nitroacetophenone
• 2,4-Dihydroxyacetophenone
• 4'-Methylacetophenone
• 2,5'-DIBROMO-2'-HYDROXYACETOPHENONE
• 3',5'-DIBROMO-4'-HYDROXYACETOPHENONE,3,5-DIBROMO-4-HYDROXYACETOPHENONE
• 6,8-DIBROMOFLAVONE