ZK756326(dihydrochloride) Chemical Properties

storage temp. 

Store at -20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

color 

White to off-white

InChI

InChI=1S/C21H28N2O3.ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;/h1-8,17,24H,9-16,18H2;1H

InChIKey

GPPMZVONOXAYET-UHFFFAOYSA-N

SMILES

C(N1CCN(CCOCCO)CC1)C1C=CC=C(OC2C=CC=CC=2)C=1.Cl

ZK756326(dihydrochloride) Usage And Synthesis

Uses

ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.

IC 50

CCR8: 1.8 μM (IC₅₀, in U87 cells); 5-HT_2B: 4.4 μM (IC₅₀); 5-HT_1A: 5.4 μM (IC₅₀); 5-HT₆: 5.9 μM (IC₅₀); 5-HT_5A: 16 μM (IC₅₀); 5-HT_2C: 34.8 μM (IC₅₀); α_2A: <20 μM (IC₅₀)

References

[1] Haskell CA, et al. Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16. DOI:10.1124/mol.105.014779

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