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Sitagliptin Impurity 10

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Sitagliptin Impurity 10 Basic information

Product Name:
Sitagliptin Impurity 10
Synonyms:
  • Sitagliptin-8
  • Sitagliptin Hydroxy Amide Impurity
  • Sitagliptin impurity 41/Sitagliptin Hydroxy Amide Impurity/3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • 3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • 1-Butanone, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-
  • (R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • 1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluo
  • Sitagliptin phosphate impurity 6
CAS:
1253056-01-7
MF:
C16H14F6N4O2
MW:
408.3
Mol File:
1253056-01-7.mol
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Sitagliptin Impurity 10 Chemical Properties

Boiling point:
542.2±60.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
13.69±0.20(Predicted)
color 
White to Off-White
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Sitagliptin Impurity 10 Usage And Synthesis

Uses

1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-1-butanone is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985), which is an impurity of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

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