t-Boc-N-Amido-PEG5-propargyl Usage And Synthesis

Description

t-Boc-N-Amido-PEG5-propargyl comprises a propargyl group and Boc-protected amine. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Boc-NH-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG5-propargyl(2062663-67-4)Related Product Information

• t-Boc-N-Amido-PEG4-propargyl
• 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID
• Boc-NH-PEG7-CH2CH2COOH
• 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester
• t-Boc-N-Amido-PEG7-propargyl
• t-boc-N-amido-PEG5-azide
• t-Boc-N-amido-PEG5-acid
• Thiol-dPEG4-t-boc-N-amido
• t-Boc-N-amido-PEG4-(CH2)3CO2H
• t-Boc-N-amido-PEG5-MS
• t-Boc-N-amido-PEG5-NHS ester
• t-Boc-N-Amido-PEG3-propargyl
• t-Boc-N-Amido-PEG6-Propargyl
• t-Boc-N-Amido-PEG4-Ms
• Boc-N-amido-PEG3-sulfonic acid
• 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
• t-Boc-N-Amido-PEG8-propargyl