1951424-89-7
1951424-89-7 Basic information
- Product Name:
- 1951424-89-7
- Synonyms:
-
- CAS_1951424-89-7
- Desthiobiotin-PEG4-propargyl
- 4-Imidazolidinehexanamide, 5-methyl-2-oxo-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-, (4R,5S)-
- Desthiobiotin Alkyne (CCT-1109)
- 6-((4R,5S)-5-Methyl-2-oxoimidazolidin-4-yl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hexanamide
- CAS:
- 1951424-89-7
- MF:
- C21H37N3O6
- MW:
- 427.54
- Mol File:
- 1951424-89-7.mol
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1951424-89-7 Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Viscous Liquid
- color
- Light yellow to yellow
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1951424-89-7 Usage And Synthesis
Uses
Desthiobiotin-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Desthiobiotin-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
1951424-89-7Supplier
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