1-Methylpiperidine-4-carboxylic acid hydrochloride Chemical Properties

Melting point:

226-228°C (dec.)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

color 

Off-white

InChI

InChI=1S/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H

InChIKey

NLUDEWJJEMHIIL-UHFFFAOYSA-N

SMILES

N1(C)CCC(C(O)=O)CC1.[H]Cl

CAS DataBase Reference

71985-80-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-24/25-36/37

HazardClass 

IRRITANT

HS Code 

29339900

1-Methylpiperidine-4-carboxylic acid hydrochloride Usage And Synthesis

Chemical Properties

Off-white solid

Synthesis

The synthesis method of 1-Methylpiperidine-4-carboxylic acid Hydrochloride is shown below: Charge isonipecotic acid, palladium, and purified water into a reaction vessel. Heat the resulting mixture to 90 to 95° C. Charge formic acid and formaldehyde to the vessel. Cool the resulting mixture to 20 to 30° C. Filter the reaction mixture through GF/F. Wash the filter cake with purified water. Concentrate the combined filtrates to ca 2 vol at atmospheric pressure. Adjust the temperature 65 to 75° C. Charge conc—hydrochloric acid to the vessel. Charge acetonitrile to the vessel at ≧70° C. and concentrate the solution to ca 2 vol at atmospheric pressure. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 2 vol. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 3 vol. Check the water content by KF analysis of the supernatant liquors using AX reagent. Cool the reaction mixture to 20 to 25° C. Stir the reaction mixture for 1 to 2 hours. Filter the reaction mixture. Wash the filter cake with acetonitrile. Dry the product up to 50° C. until ≦0.5% w/w by LOD and ≦0.2% w/w water.

1-Methylpiperidine-4-carboxylic acid hydrochloride(71985-80-3)Related Product Information

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