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2-Amino-4,6-dihydroxypyrimidine

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2-Amino-4,6-dihydroxypyrimidine Basic information

Product Name:
2-Amino-4,6-dihydroxypyrimidine
Synonyms:
  • 2-amino-6-hydroxy-4(1h)-pyrimidinon
  • 2-amino-6-hydroxy-4(1H)-Pyrimidinone
  • 2-AMino-4,6-dioxypyriMidine
  • 2-AMino-6-hydroxy-4(3H)-pyriMidinone
  • NSC 15920
  • NSC 18692
  • 2-aMino-6-hydroxypyriMidin-4(3H)-one
  • 2-AMino-4,6-dihydroxypyriMidine, 97+%
CAS:
56-09-7
MF:
C4H5N3O2
MW:
127.1
EINECS:
200-256-5
Product Categories:
  • Amines
  • Aromatics
  • 5-FOA
  • Bases & Related Reagents
  • Nucleotides
  • Heterocycles
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Nucleotides and Nucleosides
  • Pyrimidines
  • Heterocycle-Pyrimidine series
Mol File:
56-09-7.mol
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2-Amino-4,6-dihydroxypyrimidine Chemical Properties

Melting point:
>300 °C (lit.)
Boiling point:
235.85°C (rough estimate)
Density 
1.4748 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in Aqueous Alkali.
form 
Powder
pka
7.45±0.10(Predicted)
color 
Off-white to light pink or light yellow
BRN 
510297
InChIKey
AUFJTVGCSJNQIF-UHFFFAOYSA-N
CAS DataBase Reference
56-09-7(CAS DataBase Reference)
EPA Substance Registry System
2-Amino-6-hydroxy-4(1H)-pyrimidinone (56-09-7)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
1
RTECS 
UW7361000
TSCA 
Yes
HS Code 
29339900

MSDS

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2-Amino-4,6-dihydroxypyrimidine Usage And Synthesis

Description

2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine.

Chemical Properties

White Solid

Uses

2-Amino-4,6-dihydroxypyrimidine acts as an intermediate in the production of antimicrobial guanylsulfonamides. It also acts as an intermediate in pharmaceuticals and agrochemicals.

Definition

ChEBI: 2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine.

Synthesis

The synthesis of 2-Amino-4,6-dihydroxypyrimidine is as follows:
A freshly-prepared sodiummethoxide solution in methanol (25 ml) was added to a round-bottomed flask containing guanidine hydrochloride(15 mmol), stirred for a few minutes, before dimethyl malonate (15 mmol)was slowly added. The mixture was heated under reflux for about 2-3hours. After evaporation of the solvent under reduced pressure, the resultingwhite solid was dissolved in a minimum amount of water and the pH adjusted to 6with 10% HCl. The precipitate obtained was filtered and washed with distilledwater and ethanol, respectively, to obtain pure 2-amino-4,6-pyrimidinediol.(Note: sodium methoxide solution was prepared by addition of small pieces ofsodium metal in methanol).Yield: 85%;solid, m.p. 195-197 °C.

2-Amino-4,6-dihydroxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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