2-Amino-4,6-dihydroxypyrimidine Chemical Properties

Melting point:

>300 °C (lit.)

Boiling point:

235.85°C (rough estimate)

Density 

1.4748 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Soluble in Aqueous Alkali.

pka

7.45±0.10(Predicted)

form 

Powder

color 

Off-white to light pink or light yellow

BRN 

510297

InChIKey

AUFJTVGCSJNQIF-UHFFFAOYSA-N

CAS DataBase Reference

56-09-7(CAS DataBase Reference)

EPA Substance Registry System

2-Amino-6-hydroxy-4(1H)-pyrimidinone (56-09-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

1

RTECS 

UW7361000

TSCA 

Yes

HS Code 

29339900

MSDS

• Language:English Provider:2-Aminopyrimidine-4,6-diol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-4,6-dihydroxypyrimidine Usage And Synthesis

Description

2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine.

Chemical Properties

White Solid

Uses

2-Amino-4,6-dihydroxypyrimidine acts as an intermediate in the production of antimicrobial guanylsulfonamides. It also acts as an intermediate in pharmaceuticals and agrochemicals.

Definition

ChEBI: 2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine.

Synthesis

The synthesis of 2-Amino-4,6-dihydroxypyrimidine is as follows:
A freshly-prepared sodiummethoxide solution in methanol (25 ml) was added to a round-bottomed flask containing guanidine hydrochloride(15 mmol), stirred for a few minutes, before dimethyl malonate (15 mmol)was slowly added. The mixture was heated under reflux for about 2-3hours. After evaporation of the solvent under reduced pressure, the resultingwhite solid was dissolved in a minimum amount of water and the pH adjusted to 6with 10% HCl. The precipitate obtained was filtered and washed with distilledwater and ethanol, respectively, to obtain pure 2-amino-4,6-pyrimidinediol.(Note: sodium methoxide solution was prepared by addition of small pieces ofsodium metal in methanol).Yield: 85%;solid, m.p. 195-197 °C.

2-Amino-4,6-dihydroxypyrimidine(56-09-7)Related Product Information

• 1-Hydroxyethylidene-1,1-diphosphonic acid
• Iminodiacetonitrile
• Isocytosine
• CHLOROPHOSPHONAZO III
• 3-Aminophenol
• ALTRENOGEST
• 2-Amino-4,6-dichloropyrimidine
• Tris(hydroxymethyl)aminomethane
• 1,3-Dihydroxyacetone
• 6-Aminocaproic acid
• 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• Triclosan
• 4,4'-Methylenedianiline
• 4,6-Diaminopyrimidine
• 2-Amino-5-hydroxypyrimidine
• Glycine
• 2-Aminopyrimidine
• 4,6-Dihydroxypyrimidine