2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties

Melting point:

198-200 °C(lit.)

Boiling point:

349.21°C (rough estimate)

Density 

1.216

refractive index 

1.4825 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

pka

6.98±0.35(Predicted)

color 

Needles from H2O

Water Solubility 

Slightly soluble in water.

BRN 

1914746

Stability:

Hygroscopic

InChIKey

WXNRYSGJLQFHBR-UHFFFAOYSA-N

LogP

3.091 (est)

CAS DataBase Reference

131-55-5(CAS DataBase Reference)

NIST Chemistry Reference

2,2',4,4'-Tetrahydroxybenzophenone(131-55-5)

EPA Substance Registry System

2,2',4,4'-Tetrahydroxybenzophenone (131-55-5)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

DJ1892000

TSCA 

Yes

HS Code 

29145090

Hazardous Substances Data

131-55-5(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 1220mg/kg

MSDS

• Language:English Provider:2,2',4,4'-Tetrahydroxybenzophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,2',4,4'-Tetrahydroxybenzophenone Usage And Synthesis

Application

2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone.

Potential Exposure & Risk

Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound.
Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females).

Chemical Properties

yellow to brown crystalline powder

Uses

2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition.

Preparation

Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h.

Contact allergens

BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis.

Safety Profile

Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.

2,2',4,4'-Tetrahydroxybenzophenone(131-55-5)Related Product Information

• 2,3,4-Trihydroxybenzoic acid
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