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Zolpidem

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Zolpidem Basic information

Product Name:
Zolpidem
Synonyms:
  • ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
  • 6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
  • N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
  • 6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
  • 2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
  • 2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
  • N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
CAS:
82626-48-0
MF:
C19H21N3O
MW:
307.39
Product Categories:
  • Amines
  • Heterocycles
  • Pyridines derivates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotopically Labeled Pharmaceutical Reference Standard
  • (intermediate of zolpidem)
  • Zolpidem
Mol File:
82626-48-0.mol
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Zolpidem Chemical Properties

Melting point:
189-191°C
Density 
1.12±0.1 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
Store at RT
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
form 
solid
pka
6.2(at 25℃)
color 
white
Water Solubility 
<10mg/L(room temperature)
CAS DataBase Reference
82626-48-0(CAS DataBase Reference)
NIST Chemistry Reference
Zolpidem(82626-48-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
NJ5109750
HS Code 
2933996500

MSDS

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Zolpidem Usage And Synthesis

Description

Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.

Description

Zolpidem (Item No. 15792) is an analytical reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.

Description

Zolpidem (Item No. 20648) is a certified reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Originator

Synthelabo (France)

Uses

A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).

Uses

A selective benzodiazepine receptor agonist not related chemically to benzodiazepines

Definition

ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

brand name

Ambien (Sanofi Aventis);Stilnox.

General Description

Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.

Zolpidem Preparation Products And Raw materials

Raw materials

ZolpidemSupplier