Zolpidem
Zolpidem Basic information
- Product Name:
- Zolpidem
- Synonyms:
-
- ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
- N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
- 6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
- N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
- 6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
- 2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
- 2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
- N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
- CAS:
- 82626-48-0
- MF:
- C19H21N3O
- MW:
- 307.39
- Product Categories:
-
- Amines
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Isotopically Labeled Pharmaceutical Reference Standard
- Pyridines derivates
- Zolpidem
- (intermediate of zolpidem)
- Mol File:
- 82626-48-0.mol
Zolpidem Chemical Properties
- Melting point:
- 189-191°C
- Density
- 1.12±0.1 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- Store at RT
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
- form
- solid
- pka
- 6.2(at 25℃)
- color
- white
- Water Solubility
- <10mg/L(room temperature)
- CAS DataBase Reference
- 82626-48-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Zolpidem(82626-48-0)
MSDS
- Language:English Provider:SigmaAldrich
Zolpidem Usage And Synthesis
Description
Zolpidem (Item No. 15792) is an analytical reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.
Description
Zolpidem (Item No. 20648) is a certified reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.
Description
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
Chemical Properties
Off-White Solid
Originator
Synthelabo (France)
Uses
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines
Uses
A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).
Definition
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
brand name
Ambien (Sanofi Aventis);Stilnox.
General Description
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.
References
[1] S ARBILLA. Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1985, 330 3: 248-251. DOI: 10.1007/bf00572441
[2] MARJORIE CHèZE. Hair analysis by liquid chromatography–tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: Report of 128 cases over the period June 2003–May 2004 in metropolitan Paris[J]. Forensic science international, 2005, 153 1: Pages 3-10. DOI: 10.1016/j.forsciint.2005.04.021
Zolpidem(82626-48-0)Related Product Information
- 4-Methylpyridine
- Pyridine
- 1-Methylimidazole
- 2,6-Lutidine
- Acetamide
- N,N-Dimethylacetamide
- Zolpidem
- ZOLPIDEM HEMITARTRATE,ZOLPIDEM TARTRATE,Zolpidem Tartrate Tablet,ZOLPIDEM TARTRATE EP C IV
- 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE
- ZOLPIDEM TARTRATE - * PSY
- Zolpidic Acid
- Zopidem Tartrate Intermediates
- 6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]-PYRIDINE-3-ACETIC ACID (FOR ZOLPIDEM)
- Zolpidem-d6 6-Carboxylic Acid
- 2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE
- Imidazo[1,2-a]pyrimidine
- 2-(2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE
- Imidazo[1,2-a]pyridine-3-ethanamine (9CI)