2-Bromo-5-nitropyridine Chemical Properties

Melting point:

139-141 °C (lit.)

Boiling point:

145-147 °C/10 mmHg (lit.)

Density 

1.8727 (rough estimate)

refractive index 

1.6200 (estimate)

Flash point:

145-147°C/10mm

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform, Hot Methanol

form 

Crystalline Powder

pka

-3.24±0.10(Predicted)

color 

Light yellow to light brown

Water Solubility 

Insoluble in water.

BRN 

120901

InChIKey

HUUFTVUBFFESEN-UHFFFAOYSA-N

CAS DataBase Reference

4487-59-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-37/39-22-36

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT, IRRITANT-HARMFUL

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Bromo-5-nitropyridine Usage And Synthesis

Chemical Properties

Off-white to light yellow crystal.

Uses

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.

2-Bromo-5-nitropyridine(4487-59-6)Related Product Information

• 1-Hexadecylpyridinium bromide
• 2-Bromopyridine
• Chromium picolinate
• 1-Phenyl-2-nitropropene
• 2-Chloro-3-cyanopyridine
• 2-BROMO-5-METHOXYPYRIDINE
• 2-Bromo-5-methylpyridine
• 2-Bromo-6-(trifluoromethyl)pyridine
• 2-Bromo-6-methylpyridine
• 2-BROMO-5-IODOBENZYL ALCOHOL
• 2-Bromo-5-(trifluoromethyl)pyridine
• 5-Amino-2-bromopyridine
• 6-Bromonicotinic acid
• 2-BROMO-5-METHOXYANILINE
• 2-Bromo-5-chloropyridine
• 2-Bromo-5-fluoropyridine
• Nitrobenzene
• 3-Bromonitrobenzene