2,2,5,7,8-PENTAMETHYL-6-CHROMANOL Chemical Properties

Melting point:

89-91 °C (lit.)

Boiling point:

344.3±42.0 °C(Predicted)

Density 

1.034±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 250 mg/mL (1134.76 mM)

form 

solid

pka

11.41±0.40(Predicted)

color 

White

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2932990090

MSDS

• Language:English Provider:SigmaAldrich

2,2,5,7,8-PENTAMETHYL-6-CHROMANOL Usage And Synthesis

Uses

2,2,5,7,8-Pentamethyl-6-chromanol is the suitable reagent used for the quantitative analysis of α-tocopherol by plasma-based gas chromatography/tandem mass spectrometry (GC/MS/MS) using a tabletop quadrupole ion trap mass spectrometer. It may be employed as α-tocopherol model compound and on oxidation by t-butyl hydroperoxide in chloroform, in the presence of alcohol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanol. It may be used as internal standard for the determination of α- and γ-tocopherol in the rabbit serum and liver by HPLC.

General Description

2,2,5,7,8-Pentamethyl-6-chromanol has been reported as an vitamin E model compound. It undergoes oxidation in presence of various alcohols, ranging from methanol to cholesterol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanols. Antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol (PMCol), is reported to have antiandrogen activity in prostate carcinoma cells.

2,2,5,7,8-PENTAMETHYL-6-CHROMANOL(950-99-2)Related Product Information

• 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
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