Trimesic acid Chemical Properties

Melting point:

>300 °C(lit.)

Boiling point:

309.65°C (rough estimate)

Density 

1.4844 (rough estimate)

vapor pressure 

0Pa at 20℃

refractive index 

1.6000 (estimate)

Flash point:

328°C

storage temp. 

Store below +30°C.

solubility 

26.3g/l

pka

pK1: 2.12;pK2: 4.10;pK3: 5.18 (25°C)

form 

Powder

color 

white

Water Solubility 

Soluble in water, ethanol and methanol.

BRN 

2053080

Stability:

Stable, but may be light sensitive.

InChIKey

QMKYBPDZANOJGF-UHFFFAOYSA-N

LogP

1.35 at 21.41℃

CAS DataBase Reference

554-95-0(CAS DataBase Reference)

NIST Chemistry Reference

1,3,5-Benzenetricarboxylic acid(554-95-0)

EPA Substance Registry System

1,3,5-Benzenetricarboxylic acid (554-95-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

Autoignition Temperature

590 °C

TSCA 

Yes

HS Code 

29173980

Toxicity

LD50 orally in Rabbit: 16000 mg/kg

MSDS

• Language:English Provider:Trimesic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trimesic acid Usage And Synthesis

Chemical Properties

off-white powder

Uses

Trimesinic Acid is used for multifunctional therapeutics. It shows inhibitory activity against Torpedo Californica acetylcholinesterase and prevented amyloid-β peptide aggregate formation.

Uses

Trimesic acid is mainly used in the industry of poxy curing agent ,Adhesives and coating material ,Engineering plastic ,Synthetic fiber ,Cross-linking agent for alkyd resin ,Plasticizer ,Pharmaceutical intermediates, Desalination membrane etc.

Definition

ChEBI: Trimesic acid is a tricarboxylic acid that consists of benzene substituted by carboxy groups at positions 1, 3 and 5. It is a tricarboxylic acid and a member of benzoic acids. It is a conjugate acid of a benzene-1,3,5-tricarboxylate(1-).

General Description

Trimesic acid (TMA), also known as 1,3,5-benzenetricarboxylic acid, has a self-organized 2D molecular network structure formed by intermolecular hydrogen bonds between the carboxylic acid residues in bulk crystals. TMA can be used in the synthesis of metal-organic frameworks (MOFs), which can be used as organic linkers potentially utilized in sensors.

Flammability and Explosibility

Not classified

Synthesis

Trimesic acid can be produced by Friedel – Crafts methylation of toluene or xylene with chloromethane in the presence of aluminum chloride.It is also formed by liquid-phase disproportionation of xylene in the presence of aluminum chloride.These reactions can be carried out in the gas phase at high temperature on aluminum silicate catalysts.

Purification Methods

Crystallise the acid from water. The trimethyl ester has m 144o (from MeOH or MeOH/H2O). [Beilstein 9 H 978, 9 IV 3747.]

Trimesic acid(554-95-0)Related Product Information

• Pyromellitic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Hyaluronic acid
• Folic acid
• Citric acid
• Ascoric Acid
• TRIMESIC ACID TRICHLORIDE,Benzene-1,3,5-tricarbonyl chloride, Trimesic acid trichloride, Trimesoyl chloride
• MELLITIC ACID
• BENZENEPENTACARBOXYLIC ACID
• TRIMESIC ACID TRIETHYL ESTER,Trimesic acid triethyl
• TRIMESIC ACID TRIMETHYL ESTER
• MELLITIC TRIANHYDRIDE
• BENZENEHEXACARBOXYLIC ACID HEXAMETHYL ESTER
• TRIMESIC ACID TRIALLYL ESTER
• 2,4,6-TRICARBOXYBENZOTRIFLUORIDE
• DIETHYL 1,3,5-BENZENETRICARBOXYLATE
• TRIS-[11-PENTAKIS-(4'-PROPYLPHENYLETHYNYL)PHENOXYUNDECYL]TRIMESATE
• 1,3,5-BENZENE-2,4,6-D3-TRICARBOXYLIC ACID