BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

clear liquid

color 

Colorless to Light yellow to Light orange

InChI

InChI=1S/C20H39NO10/c1-20(2,3)31-19(24)21-5-7-26-9-11-28-13-15-30-17-16-29-14-12-27-10-8-25-6-4-18(22)23/h4-17H2,1-3H3,(H,21,24)(H,22,23)

InChIKey

FTTYOIHYERRXQB-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCCOCCOCCC(O)=O

Safety Information

WGK Germany 

3

HS Code 

29225090

BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Usage And Synthesis

Description

t-Boc-N-amido-PEG6-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Yellow liquid

Uses

Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

IC 50

Cleavable Linker; Alkyl/ether; PEGs

References

[1] Michael J. Mcpherson, et al. Glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471A1.

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