Z-VDVAD-FMK
Z-VDVAD-FMK Basic information
- Product Name:
- Z-VDVAD-FMK
- Synonyms:
-
- BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
- CASPASE-2 INHIBITOR I
- Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE
- Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
- Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK
- Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE
- Z-VDVAD-FLUOROMETHYLKETONE
- Z-VDVAD-FMK
- CAS:
- 210344-92-6
- MF:
- C32H46FN5O11
- MW:
- 695.73
- Product Categories:
-
- Caspases/Apoptosis
- Caspase/Related Products
- Mol File:
- Mol File
Z-VDVAD-FMK Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO/DMF: 20 mM
- form
- powder
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
Z-VDVAD-FMK Usage And Synthesis
Biological Activity
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Biochem/physiol Actions
A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.
References
1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.
Z-VDVAD-FMKSupplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 0330-2528181
- sales@vdmbio.com
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
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