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ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Basic information

Product Name:
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide
Synonyms:
  • 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide
  • 2-Pyridinecarboxamide, 4-[3-fluoro-4-[[2-[(methylamino)carbonyl]-4-pyridinyl]amino]phenoxy]-N-methyl-
  • Regorafenib Dipyrimidine
  • 4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide formate
  • Regorafenib Impurities69
  • Azilsartan medoxomil impurity263
  • Regorafenib Impurities04
  • Regorafenib Impurities11
CAS:
1855006-12-0
MF:
C20H18FN5O3
MW:
395.39
Mol File:
1855006-12-0.mol
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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Chemical Properties

Boiling point:
631.8±55.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
pka
13.92±0.46(Predicted)
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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Usage And Synthesis

Uses

Regorafenib Dipyrimidine is an impurity of Regorafenib(R143000); which inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.

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