TCID Chemical Properties

Melting point:

218-220

Boiling point:

448.1±45.0 °C(Predicted)

Density 

1.782±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

Soluble in DMSO (up to 25 mg/ml),

form 

Orange solid

pka

8.62±0.20(Predicted)

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

TCID Usage And Synthesis

Description

TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.

Uses

TCID is a small molecule inhibitor of DNA polymerase λ.

storage

Store at -20°C

References

1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022

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