TCID Chemical Properties

Melting point:

218-220

Boiling point:

448.1±45.0 °C(Predicted)

Density 

1.782±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

Soluble in DMSO (up to 25 mg/ml),

form 

Orange solid

pka

8.62±0.20(Predicted)

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

TCID Usage And Synthesis

Description

TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.

Uses

TCID is a small molecule inhibitor of DNA polymerase λ.

storage

Store at -20°C

References

[1] KERRY ROUTENBERG LOVE. Mechanisms, biology and inhibitors of deubiquitinating enzymes[J]. Nature chemical biology, 2007, 3 11: 697-705. DOI:10.1038/nchembio.2007.43
[2] NAMDORI R. MTANGO. Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation[J]. Journal of Cellular Physiology, 2011, 227 5: 2022-2029. DOI:10.1002/jcp.22931

TCID(30675-13-9)Related Product Information

• Ninhydrin hydrate
• Ninhydrine, ozone friendly ready to use spray for TLC chromatography
• BINDONE
• DIPHACINONE
• 2-NITRO-1,3-INDANDIONE
• 2-ISOVALERYL-1,3-INDANEDIONE
• 2-BENZOYL-1,3-INDANEDIONE
• Bromindione
• 2-(DICYANOMETHYLENE)INDAN-1,3-DIONE
• PINDONE
• 2-PHENYL-1,3-INDANDIONE
• Solvent Yellow 33
• HYDRINDANTIN
• Disperse Yellow 64
• Chlorophacinone
• Indan
• 1,3-Indanedione
• 2-((4-CHLOROPHENYL)METHYLENE)INDANE-1,3-DIONE