3-BROMO-5-METHYLBENZONITRILE Chemical Properties

Melting point:

57-58.5℃

Boiling point:

256.1±20.0℃ (760 Torr)

Density 

1.51±0.1 g/cm3 (20 ºC 760 Torr)

Flash point:

108.7±21.8℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

solid

color 

White to off-white

Safety Information

HS Code 

2926907090

3-BROMO-5-METHYLBENZONITRILE Usage And Synthesis

Uses

3-Bromo-5-methylbenzonitrile is used in the synthesis of arenes with high steric regiocontrol.

Synthesis

Example 45 Synthesis of 3-bromo-5-methylbenzonitrile: Phosphorus pentoxide (29.8 g, 210.2 mmol) was added to a chloroform suspension of 3-bromo-5-methylbenzamide (15.0 g, 70.1 mmol), and the reaction mixture was stirred under reflux conditions for 2 days (the reaction progress was monitored by thin layer chromatography). Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water with stirring. The organic layer was separated and the aqueous layer was extracted with dichloromethane (150 mL x 2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate. Purification by fast column chromatography afforded the target product 3-bromo-5-methylbenzonitrile (7.20 g, 52% yield).1H NMR (400 MHz, CDCl3) δ 7.60-7.56 (m, 2H), 7.40-7.39 (m, 1H), 2.39 (s, 3H).

References

[1] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 53
[2] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 56; 57
[3] Patent: US2009/197871, 2009, A1. Location in patent: Page/Page column 56
[4] Patent: WO2009/100169, 2009, A1. Location in patent: Page/Page column 137

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