D-Aspartic acid Chemical Properties

Melting point:

>300 °C(lit.)

alpha 

-25.8 º (c=5, 5N HCl)

Boiling point:

245.59°C (rough estimate)

Density 

1.66

refractive index 

-25 ° (C=8, 50% HCl)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Aqueous Acid (Sparingly)

pka

pK1: 1.89(0);pK2: 3.65;pK3: 9.60 (25°C)

form 

Crystalline Powder

color 

White to off-white

optical activity

[α]20/D 24°, c = 2.3 in 6 M HCl

Water Solubility 

SOLUBLE

Merck 

14,840

BRN 

1723529

InChIKey

CKLJMWTZIZZHCS-UWTATZPHSA-N

LogP

-1.075 (est)

CAS DataBase Reference

1783-96-6(CAS DataBase Reference)

NIST Chemistry Reference

D-aspartic acid(1783-96-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

RTECS 

CI9097500

HS Code 

29224995

MSDS

• Language:English Provider:D-Aminosuccinic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

D-Aspartic acid Usage And Synthesis

Chemical Properties

White or almost white crystalline powder

Uses

D-Aspartic acid modulates melatonin synthesis in the pineal gland.

Uses

A non-essential amino acid found in food sources and dietary supplements. D-Aspartic acid's conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.

Definition

ChEBI: The D-enantiomer of aspartic acid.

reaction suitability

reaction type: solution phase peptide synthesis

Biological Activity

Endogenous NMDA receptor agonist with similar activity to the L-isomer (L-Aminosuccinic acid ). Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.

Synthesis

In a reaction vessel, 4.85 g (0.03 mol) of dimethyl (S)-2-aminosuccinate was added to 50 mL of 6 M potassium hydroxide solution and the hydrolysis reaction was carried out by heating and refluxing for 3 hrs. Upon completion of the reaction, the pH of the reaction solution was adjusted to 6.5 with 6 N hydrochloric acid.The reaction solution was purified by passing it through a regenerated cation exchange resin column and the effluent with pH=4 was collected. The collected effluent was concentrated under reduced pressure to one-fifth of the original volume and then precipitated by adding 95% methanol. The precipitate was collected by filtration and dried to give 3.3 g of D-aspartic acid in 82.5% yield.

storage

Room temperature

References

[1] Patent: CN105503628, 2016, A. Location in patent: Paragraph 0026

D-Aspartic acid(1783-96-6)Related Product Information

• FMOC-ASN(TRT)-OPFP
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• DL-Aspartic acid magnesium salt tetrahydrate
• L-ASPARTIC ACID
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• Ascoric Acid
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