2,3-DCPE HYDROCHLORIDE Chemical Properties

Boiling point:

402.9±40.0 °C(Predicted)

Density 

1.259±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at -20°C

solubility 

20 mg/ml in DMSO

pka

14.78±0.10(Predicted)

form 

Powder

Water Solubility 

Soluble in water at ~25 mg/ml. Also soluble in ethanol, DMSO or DMF at ~20mg/ml. Soluble in PBS, pH 7.2 at ~10 mg/ml.

2,3-DCPE HYDROCHLORIDE Usage And Synthesis

Uses

2,3-DCPE induces apoptosis and downregulates Bcl-XL expression. 2,3-DCPE has anti-tumor activity and can be used in cancer research[1].

Biological Activity

Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro . IC 50 values are 0.89 and 12.6 μ M for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

References

[1] Wu S, et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 2004 Feb 1;64(3):1110-3. DOI:10.1158/0008-5472.can-03-2790

2,3-DCPE HYDROCHLORIDE(418788-90-6)Related Product Information

• 3-(3-CHLOROPHENOXY)-N-METHYLPROPAN-1-AMINE
• 3-(3-chlorophenoxy)propan-1-amine
• 2,3-DCPE HYDROCHLORIDE