Isopropylparaben Chemical Properties

Melting point:

84-86°C

Boiling point:

160 °C / 5mmHg

Density 

1.132±0.06 g/cm3(Predicted)

vapor pressure 

0.155Pa at 25℃

storage temp. 

Sealed in dry,2-8°C

solubility 

Soluble in Chloroform, Ethyl Acetate.

form 

powder to lump

pka

8.40±0.15(Predicted)

color 

White

Water Solubility 

1.204g/L

BRN 

2641564

LogP

2.316 at 25℃

CAS DataBase Reference

4191-73-5(CAS DataBase Reference)

NIST Chemistry Reference

Isopropyl-4-hydroxybenzoate(4191-73-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RTECS 

DH2250000

HazardClass 

IRRITANT

HS Code 

2918290090

MSDS

• Language:English Provider:ALFA

Isopropylparaben Usage And Synthesis

Chemical Properties

White Solid

Uses

It is used as a preservative in cosmetics.

Uses

An antimicrobial

Definition

ChEBI: Isopropylparaben is a 4-hydroxybenzoate ester.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Synthesis

GENERAL METHOD: Thionyl chloride (1.16 g, 1.5 eq.) was slowly added dropwise to a solution of p-hydroxybenzoic acid (1.0 g, 1.0 eq.) dissolved in isopropanol (15 ml) at 0 °C. The reaction mixture was heated to reflux under nitrogen protection until thin layer chromatography (TLC) monitoring showed complete consumption of p-hydroxybenzoic acid. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate/hexane to give the final isopropyl 4-hydroxybenzoate.

References

[1] Synthesis, 2003, # 16, p. 2479 - 2482
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2004, vol. 179, # 6, p. 1187 - 1191
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 6, p. 1564 - 1569
[4] Journal of the Society of Chemical Industry, London, 1947, vol. 66, p. 175
[5] Archiv der Pharmazie (Weinheim, Germany), 1938, vol. 276, p. 154,162

Isopropylparaben(4191-73-5)Related Product Information

• Ethylparaben
• Propyl acetate
• Isopropyl palmitate
• ISOPROPYL LAURATE
• BUTYL OLEATE
• Dimethyl succinate
• Isopropyl alcohol
• Methyl acrylate
• Methyl salicylate
• Methylparaben
• Propyl gallate
• Isopropyl acetate
• Tris(trimethylsilyl)phosphate
• (-)-Epigallocatechin gallate
• SYROSINGOPINE
• Deserpidine
• ISOPROPYLGALLATE
• ALPHA-ZEARALENOL