Basic information Clinical Uses lnstructions for Use Adverse Reactions and Side Effects Safety Supplier Related
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Hydroxyethyl starch

Basic information Clinical Uses lnstructions for Use Adverse Reactions and Side Effects Safety Supplier Related

Hydroxyethyl starch Basic information

Product Name:
Hydroxyethyl starch
Synonyms:
  • 2-hydroxyethylstarchether
  • essex1360
  • 2-HYDROXYETHYL STARCH
  • essexgum1360
  • ethylexgum2020
  • hes
  • hespander
  • hespanderinjection
CAS:
9005-27-0
MF:
(C6H10O5)m(C2H5O)n
MW:
0
EINECS:
618-410-9
Product Categories:
  • API
  • Carbohydrates
  • Carbohydrates A to
  • Carbohydrates H-LBiochemicals and Reagents
  • Polysaccharide
Mol File:
Mol File
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Hydroxyethyl starch Chemical Properties

storage temp. 
-20°C
solubility 
Freely soluble in water and in dimethyl sulfoxide, practically insoluble in anhydrous ethanol. Hydroxyethyl starches are hygroscopic until they reach a water content of about 12 per cent to 15 per cent.
form 
neat
CAS DataBase Reference
9005-27-0(CAS DataBase Reference)
EPA Substance Registry System
Starch, 2-hydroxyethyl ether (9005-27-0)
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Safety Information

WGK Germany 
2
RTECS 
WI0410000

MSDS

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Hydroxyethyl starch Usage And Synthesis

Clinical Uses

Hydroxyethyl starch is often used as a plasma substitute for therapy of hypo- volemia after trauma, burns, infections or during surgery.It is also widely used for hemodilution treatment of cerebral ischemia and of retinal, otogenic or peripheral perfusion disturbances.In treatment of cerebral ischemia, a hypervolemic therapy protocol has been shown to be more effective than an isovolemic infusion. Another indication is the hyperdynamic treatment of vasospasm in subarachnoid hemorrhage.Some of these indications require relatively high dosages to ensure efficacy of therapy.However, during continuous treatment with large volumes of HES, disturbances of coagulation and hemor- rhagic complications are not uncommon. Trumble et al. reported bleeding complications during hetastarch therapy of vasospasm in subarachnoid hemorrhage patients and recommended the use of plasma protein fraction instead.Van den Brink observed coagulopathy under therapy with highly sub- stituted medium molecular weight HES.These disturbances of the coagulation sys-tem were found to be due to an acquired von Willebrand syndrome.

lnstructions for Use

Suspend in saline(0.9%) or 5% dextrose solution for use. Administer slowly in 5-mL/kg increments to small animals,then reassess and increase the dose to rates listed in the dosing section.Hydroxyethyl starch solutions are used in critical care situations and infused via CRI.

Adverse Reactions and Side Effects

Most of the serious adverse effects reported, such as kidney injury and coagula- tion abnormalitics,have been observed in human studies and have not been docu- mented with clinical use in veterinary medicine.The use in people has become controversial and caution is advised when using these products in animals,with attention to the most commonly reported problems in people.Hetastarch may cause allergic reactions and hyperosmotic kidney injury.Hydroxyethyl starch solu- tions may affect platelet function and produce coagulation abnormalitics at clini- cally relevant doses for up to 24 hours.The high-molecular-weight hetastarch may alter coagulation and alter viscoelastic measurements and fibrinolysis.Do not use in patients with bleeding problems or preexisting coagulopathies. High-molecular- weight products (10% solutions) have molecular weight more than 200 kDa (kilodaltons)and are associated with higher risk of kidney injury.Tetrastarch solu- tions also may have less tendency to cause coagulopathics than hetastarch.There- fore the current recommendation is to use tetrastarch solutions of 6% and reduced molecular weight(130 kDa).

Chemical Properties

DS 0.7;

Uses

blood volume expander

brand name

Pentaspan (DuPont Merck).

Hydroxyethyl starchSupplier

Chongqing Daxin Pharmaceutical Co.,Ltd. Gold
Tel
023-61301919
Email
xzb@daxinpharm.com
Jinan Ruixing Pharmaceutical technology Co., Ltd. Gold
Tel
531-88883606;531-88895311
Email
sales@jnrxchem.com;sales@jnrxchem.com
Jinan MaoFuYi Chemical Co., Ltd. Gold
Tel
0531-88996911
Email
3305202763@qq.com
Wuhan Fortuna Chemical Co., Ltd Gold
Tel
027-59207852-
Email
buy@fortunachem.com
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Email
sales@RHFChem.com