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ISOTETRANDRINE

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ISOTETRANDRINE Basic information

Product Name:
ISOTETRANDRINE
Synonyms:
  • 1-isotetrandrine
  • 6,6’,7,12-tetramethoxy-2,2’-dimethyl-berbama
  • isosinomenina
  • isosinomeninea
  • o,o’-dimethylobamegine
  • o,o’-dimethylstepholine
  • O-METHYLBERBAMINE
  • BERBAMINE METHYL ETHER
CAS:
477-57-6
MF:
C38H42N2O6
MW:
622.76
Product Categories:
  • Alkaloids
Mol File:
477-57-6.mol
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ISOTETRANDRINE Chemical Properties

Melting point:
180-182℃
Boiling point:
710.5±60.0 °C(Predicted)
Density 
1.172
RTECS 
NX7285000
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Off-white solid.
pka
7.70±0.20(Predicted)
color 
White to light yellow
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ISOTETRANDRINE Usage And Synthesis

Description

A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]17D + 146° or[α]20D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

Uses

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

target

IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK

References

Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)

ISOTETRANDRINESupplier

BioBioPha Co., Ltd. Gold
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0871-65217109 13211707573;
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y.liu@mail.biobiopha.com
Chembest Research Laboratories Limited
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+86-21-20908456
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sales@BioChemBest.com
Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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tauto@tautobiotech.com
AdooQ BioScience, LLC
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+1 (866) 930-6790
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info@adooq.com
ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396
Email
sales@chem-strong.com
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