1-Chloroethyl isopropyl carbonate Chemical Properties

Boiling point:

70 °C / 15mmHg

Density 

1.113±0.06 g/cm3(Predicted)

refractive index 

1.4110-1.4150

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Almost colorless

InChI

InChI=1S/C6H11ClO3/c1-4(2)9-6(8)10-5(3)7/h4-5H,1-3H3

InChIKey

XPTPAIJDVFQPJT-UHFFFAOYSA-N

SMILES

C(OC(C)C)(=O)OC(Cl)C

LogP

1.37 at 20℃

CAS DataBase Reference

98298-66-9(CAS DataBase Reference)

Safety Information

Risk Statements 

10-34

Safety Statements 

16-36/37/39

RIDADR 

2920

HS Code 

2915.90.5010

HazardClass 

8/3

PackingGroup 

II

1-Chloroethyl isopropyl carbonate Usage And Synthesis

Uses

1-Chloroethyl Isopropyl-d7 Carbonate is an intermediate in the synthesis of Cefpodoxime Proxetil-d7 (C243862). Cefpodoxime Proxetil-d7 is the labelled form of Cefpodoxime Proxetil (C243860), an antibacterial. Cefpodoxime Proxetil is a broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime (C243850).
1-Chloroethyl isopropyl carbonate is an efficient and mild reagent for removing benzyl protecting groups, especially for compounds containing functional groups that are easily reduced.

Synthesis

To a solution of 2-propanol (2.66 mL, 34.97 mmol) and pyridine (3.39 mL, 41.96 mmol), pre-cooled in a dry-ice/acetone bath was slowly added 1-chloroethyl chloroformate. The resulting mixture was allowed to slowly warm to 25° C. overnight, with stirring. After concentration under reduced pressure, the mixture was dissolved in ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to give 1-chloroethyl isopropyl carbonate as a pink/orange oil (5.11 g, 88% yield).

1-Chloroethyl isopropyl carbonate(98298-66-9)Related Product Information

• Isopropyl alcohol
• Sodium carbonate
• N,N-Diisopropylethylamine
• ISOPROPYL LAURATE
• Chloromethyl isopropyl carbonate
• Polycarbonate
• Barium carbonate
• Zinc carbonate
• Isopropyl acetate
• Ethylene carbonate
• Vinylene carbonate
• Calcium carbonate
• Dimethyl carbonate
• Propylene carbonate
• Ammonium carbonate
• 1-Chloroethyl cyclohexyl carbonate
• Chloromethyl ethyl carbonate
• 1-Chloroethyl ethyl carbonate