1-Ethylpiperazine Chemical Properties

Melting point:

-60 °C

Boiling point:

157 °C(lit.)

Density 

0.899 g/mL at 25 °C(lit.)

vapor pressure 

2.48hPa at 20℃

refractive index 

n20/D 1.469(lit.)

Flash point:

110 °F

storage temp. 

2-8°C

solubility 

soluble

form 

Liquid

pka

9.27±0.10(Predicted)

Specific Gravity

0.899

color 

Clear colorless to yellow

Water Solubility 

soluble

Sensitive 

Air Sensitive

BRN 

102971

InChIKey

WGCYRFWNGRMRJA-UHFFFAOYSA-N

LogP

-0.1 at 20℃

CAS DataBase Reference

5308-25-8(CAS DataBase Reference)

NIST Chemistry Reference

N-ethylpiperazine(5308-25-8)

EPA Substance Registry System

Piperazine, 1-ethyl- (5308-25-8)

Safety Information

Hazard Codes 

Xi,Hazard

Risk Statements 

36/37/38-10

Safety Statements 

26-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

1

RTECS 

TM0815500

F 

10-34

HazardClass 

3

PackingGroup 

III

HS Code 

29335995

MSDS

• Language:English Provider:1-Ethylpiperazine
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1-Ethylpiperazine Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

Uses

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammability and Explosibility

Flammable

1-Ethylpiperazine(5308-25-8)Related Product Information

• 1-Methylpiperazine
• Piperacillin
• 2-Ethylhexyl ferulate
• Piperazine
• Levodropropizine
• 2-Ethylpiperazine
• Piperazine-N,N'-bis-(2-ethanesulphonic acid) dipotassium salt
• 1,4-Bis(3-aminopropyl)piperazine
• HEPPS
• Triethylenediamine
• 1-(3-AMINOPROPYL)-4-METHYLPIPERAZINE
• 1-(4-Chlorobenzhydryl)piperazine
• HEPES
• 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
• Trifluoperazine dihydrochloride
• 4-[2-(PIPERAZIN-1-YL)-ACETYL]-MORPHOLINE
• N-Aminoethylpiperazine
• 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE