1-Ethylpiperazine Chemical Properties

Melting point:

-60 °C

Boiling point:

157 °C(lit.)

Density 

0.899 g/mL at 25 °C(lit.)

vapor pressure 

2.48hPa at 20℃

refractive index 

n20/D 1.469(lit.)

Flash point:

110 °F

storage temp. 

2-8°C

solubility 

soluble

form 

Liquid

pka

9.27±0.10(Predicted)

Specific Gravity

0.899

color 

Clear colorless to yellow

Water Solubility 

soluble

Sensitive 

Air Sensitive

BRN 

102971

InChI

1S/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3

InChIKey

WGCYRFWNGRMRJA-UHFFFAOYSA-N

SMILES

CCN1CCNCC1

LogP

-0.1 at 20℃

CAS DataBase Reference

5308-25-8(CAS DataBase Reference)

NIST Chemistry Reference

N-ethylpiperazine(5308-25-8)

EPA Substance Registry System

Piperazine, 1-ethyl- (5308-25-8)

Safety Information

Hazard Codes 

Xi,Hazard

Risk Statements 

36/37/38-10

Safety Statements 

26-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

1

RTECS 

TM0815500

F 

10-34

HazardClass 

3

PackingGroup 

III

HS Code 

29335995

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1B
STOT SE 3

MSDS

• Language:English Provider:1-Ethylpiperazine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Ethylpiperazine Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

Uses

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammability and Explosibility

Flammable

Synthesis

Method one is to synthesize piperazine as raw material: piperazine is prepared by reacting with acetonitrile, acetaldehyde or ethyl bromide. The method of synthesizing N-ethyl piperazine by reaction of piperazine and ethyl bromide has the features of simple production process and less by-products, which is a new process with more research in China, but the reaction has the fatal shortcomings of high production cost and low profit margin, which seriously restricts the industrialization of this process, and at the same time, in the process of reaction of piperazine and ethyl bromide, there are inevitably more by-products of N,N-Diethylpiperazine generation. The second method is to synthesize with ethylamine as raw material: ethylamine and ethylene oxide are prepared by addition and cyclization. The disadvantages of this method are high reaction temperature, resulting in high equipment requirements; more reaction steps, more equipment instrumentation, resulting in process control, three waste disposal difficulties; poor catalyst selectivity, low conversion rate, more by-products.

1-Ethylpiperazine(5308-25-8)Related Product Information

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